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BCG VaccineBCG or Bacillus Calmette Guerin is a vaccine used for prevention of Tuberculosis(TB) in humans since 1921.Approximately 100 million children were administered (vaccinated) with BCG in almost 170 countries in the world.The BCG vaccine is prepared from a strain of attenuated,live tuberculosis bacilli' Mycobacterium Bovis. That has lost it's virulence in humans by being specially cultered in an artificial medium for years.The bacilli have retained enough strong antigenecity to become an effective Vaccine for the prevention of tuberculosis in human beings.

BCG Vaccine is one of the most widely used vaccines in the world. Its efficacy against TB meningitis in the pediatric age-group is established; but its efficacy against pulmonary TB is appears to be variable. Many countries use BCG for prevention of TB. But a few countries like U.S, they do not use BCG for routine vaccination. This is probably because they believe in detecting the active disease by a reliable Mantoux test, instead of practicing the routine vaccination against a relatively rare condition i.e, the incidence of TB is very low.

Efficacy:-The most controversial aspect of BCG is its variable efficacy when used in various clinical trials. This appears to depend on the geography. The efficacy of 14% to 84% upto 5 years after immunization. However a clinical trials conducted in South India showed no protective effect.

BCG VaccineBut BCG vaccine seems to be very effective in preventing miliary TB & TB meningitis. Hence it is still extensively used in countries where efficacy against pulmonacy TB is negligible.

The possible reasons for variable efficacy are many:

  • Genetic variation of the population
  • Genetic variation in BCG strains used
  • Background exposure to the disease-TB.
  • Non-specific immune responses against Mycobacteria by non-tuberculous mycobacteria
  • Immune response with simultaneous infection with parasites, which may blunt the effect of BCG

Adverse effects:- BCG is one of the widely used vaccines with on unparalleled safety record.

It is recommended that BCG vaccine be given by intra-dermal injection by staff skilled in the technique. BCG immunization causes pain & leaves a scar at the site of injection. The main adverse effects are keloids or large, ugly scars. The insection of deltoid is used for BCG vaccination, because of the least complication when that site is used.

Adverse events to BCG vaccine are mostly localized, and long term complication are rare. If the vaccine is given subcutaneously, it causes a local skin reaction, spreading to the regional lymph adenitis and may cause suppurative lymphadenitits.

95% of subjects vaccinated with BCG develop a local reaction like erythema, induration, muscle soreness, ulceration etc., which is followed by healing & scar formation within 3 months.

Other complication include osteitis (0.01 per million in Japan) & disseminated BCG diseases (0.19 to 1.56 cases per million.

The BCG vaccinated people may not give the potency ratios of the same order as that of naturally infected individuals because of the fact that BCG vaccination leads to a relatively low degree of sensitisation and it may be of a different specificity.

BCG Policy:-

WHO Policy:- WHO recommends that BCG be given to all children born in countries highly endemic for Tuberculois because it offers protection against TB meningitis and miliary TB.

INDIA introduced BCG mass immunization in the year 1948, the first Non-European country to do so.